Activities
The
platform is key in the validation of new animal models of neurodegenerative
pathologies and in the evaluation of the efficacy, biodistribution and safety
of the newly tested biotherapies (drugs, stem cells, viral vectors, etc …).
Techniques
1.histology
- Sampling
and preparation of samples (tissue fixation and/or freezing)
- Histological
sections acquired with vibratome, microtome, or cryostat
- Immunohistochemistry
and immunofluorescence labeling, simple or co-labeling
- Histochemical
staining to observe structural details in tissues
- Enzyme
activity labeling
- In situ hybridization to characterize the presence of specific RNA inside a cell
- Immunostaining
and clearing of biological samples (iDISCO)
- Macroscopic or microscopic image acquisition
- Analysis
with dedicated software
